The risk factors for mortality in non-human immunodeficiency virus infected children with pneumocystis carinii pneumonia

Abstract

Objective To analyze the epidemiologic characteristics and risk factors for mortality in non-(human immunodeficiency virus, HIV) infected children with pneumocystis carinii pneumonia(PCP). Methods The data of non-HIV infected children with PCP diagnosed in Beijing Children's Hospital from January 1, 2006 to December 31, 2012 were collected.They were divided into survival and non-survival group according to the prognosis.The epidemiologic characteristics and risk factors for mortality were analyzed. Results Sixteen patients were enrolled in this study.Ten of them survived and 6 of them were non-survived.The basic diseases included malignant tumor in 5 patients and non-malignancy diseases in 11 of them.Compared with the survival group, the non-survival group had a higher average age [(12.00±2.00)years vs.(6.65±4.32)years, P=0.01], higher ratio to need mechanical ventilation (6/6 vs.4/10, P=0.04), lower PaO2/FiO2[(73.88±26.95) mmHg vs.(167.50±97.17) mmHg, 1 mmHg=0.133 kPa, P=0.01] and lower pediatric critical illness score(75.67±5.72 vs.86.40±8.88, P=0.02). There were no differences on sex ratio, kinds of basic diseases, whether with co-infections, the time of immunosuppressant administration, the time from onset to diagnosis, the time from onset to beginning trimethoprim-sulfamethoxazole therapy, PaCO2, white blood cell counts, lymphocyte counts, cell counts, C-reactive protein, and hemoglobin concentrations between the survival and non-survival group. Conclusion A higher age, need for mechanical ventilation, lower PaO2/FiO2 and lower pediatric critical illness score were risk factors for mortality in non-HIV infected children with PCP. Key words: Non-human immunodeficiency virus infection; Pneumocystis carinii pneumonia; Epidemiology; Risk factors; Mortality; Children