Abstract
It took 40 years for the hepatitis E virus (HEV) to grow from a suspected waterborne agent of hepatitis outbreaks in India,1 to the most common cause of acute viral hepatitis worldwide, and a crucial issue for the European Association for the Study of the Liver.2 HEV belongs to the Hepeviridae: a family of viruses that can infect mammals, birds, and fish. Human pathogenic strains are found within the Orthohepevirus A species divided in genotypes: HEV-1 and -2 are restricted to humans; HEV-3 and -4 infect both humans and animals, and pigs are the main reservoir, along with deer, wild boars, and rabbits.
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