The rise and decline of serum S100B in traumatic brain injury in humans with focus on the temporal profile and correlation to outcome

Abstract

Event Abstract Back to Event The rise and decline of serum S100B in traumatic brain injury in humans with focus on the temporal profile and correlation to outcome Eric Thelin1* 1 Karolinska Institutet, Clinical Neuroscience, Sweden Traumatic brain injury (TBI) is among the leading causes of mortality and disability among adults worldwide. There is a need for prognostic markers that can be used to predict outcome and to monitor the current care of neuro-critical care patients. The protein S100B exists mainly in the central nervous system and is by far the most studied biomarker in TBI. Still, there are areas concerning the temporal profile and increases of the serum concentration of the protein that requires clarification. We have performed a retrospective analysis of 265 patients admitted to the neuro-intensive care unit (NICU) at the Karolinska University Hospital was retrospectively analyzed with focus on serum levels of S100B in relation to time of trauma and release pattern. A different set of patients were also analyzed concerning the occurrence of secondary increases in the serum levels of S100B during their NICU stay to examine the dynamics and cause of these secondary serum increases. Two different release patterns were recognized with one group that had the highest serum concentration immediately following trauma (Decliners) and another group that had increasing serum levels during several days (Climbers). The Climbers did not present higher peak levels of S100B than the Decliners, but presented a significant worse outcome. Patients with secondary increases of S100B were also found to have secondary insults on radiological examinations in about 95% of the cases. Ischemic injuries were found to have the greatest impact on secondary increase of S100B. The temporal pattern and occurrence of secondary peaks in serum levels of S100B and the implication on outcome will be discussed. Keywords: biomarker, Intensive Care, Monitoring, Outcome, S100B, secondary insults, Traumatic Brain Injury Conference: Karolinska Institutet 200 years anniversary Symposium on Traumatic Injuries in the Nervous System, Stockholm, Sweden, 15 Sep - 16 Sep, 2010. Presentation Type: Presentation Topic: Traumatic Injuries in the Nervous System Citation: Thelin E (2010). The rise and decline of serum S100B in traumatic brain injury in humans with focus on the temporal profile and correlation to outcome. Front. Neurol. Conference Abstract: Karolinska Institutet 200 years anniversary Symposium on Traumatic Injuries in the Nervous System. doi: 10.3389/conf.fneur.2010.56.00003 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 07 Sep 2010; Published Online: 21 Sep 2010. * Correspondence: Dr. Eric Thelin, Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden, eric.thelin@ki.se Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Eric Thelin Google Eric Thelin Google Scholar Eric Thelin PubMed Eric Thelin Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.