Abstract
Chronic obstructive pulmonary disease (COPD) is a global, prevalent, underdiagnosed, and neglected condition characterized by progressive respiratory symptoms, airflow obstruction, limitation in activity, and an inflammatory response of the lung to noxious insult [1]. The natural history of COPD is punctuated by acute deteriorations in respiratory health termed “exacerbations,” and these exacerbations are responsible for much of the disease burden [2]. Most exacerbations are caused by airway infection [3], and many effective interventions are now available to reduce exacerbation occurrence.
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