Abstract
Azithromycin is broad spectrum macrolide antibiotic with long half life and excellent tissue penetration. Azithromycin is an azalide antimicrobial agent active in vitro major pathogens responsible for infectious of the respiratory tract, skin and soft tissue in children. In children azithromycin is usually given as either a 3- day course of 10 mg/kg/day on the first day,followed by 5 mg/kg/day for a further 4 days. Azithromycin is a subclass of microlide antibiotics. It is derived from erythromycin with a methyl–substituted nitrogen atom incorporated in lactone ring, thus making the lacctone ring 15-membered. Pathogen that are generally susceptible to azithromycin include Haemophilus influenzae (including ampicillin-resistant strains), Moraxella catarrhalis, Chalmydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumoniae Streptococcus pyogens and streptococcus agalactiae. Azithromycin is administerd once daily achieves clinically relevent concentration at sites of infection, is slowly eliminated from the body and has few drug interaction.A five day treatment administration (500 mg on day 1 followed by 250 mg on days 2-5 ) or a three day regimen (500 mg daily for three days).
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