The review of fundamental retrosynthetic analysis and simple practical to hydroxychloroquine

Abstract

In this paper, we discussed the basic mechanism of retrosynthetic analysis. We start with the idea of disconnection, which is a hypothesis to break the target molecule into some relatively simpler and more common molecules. Then we break bonds to verify our hypothesis made during disconnect. Based on the number and location of the functional groups, we can apply different methods for retrosynthetic analysis. We also apply our research of retrosynthetic analysis on the synthesis of hydroxychloroquine. In the second part of our paper, we discussed which method is more efficient to synthesize hydroxychloroquine, which should simplify the steps as much as possible, reduce the need for special conditions such as temperature, pressure, etc., and reduce waste liquid pollution, to ensure the ultimate industrial production effect.