Abstract
In this paper we present the study of chemotherapy and radiotherapy treatment success in children suffering from Hodgkin's disease (HD) that were treated at Hematology-oncology Department of Pediatric Clinic in Sarajevo. In retrospective study we followed all patients with HD aged 0-15 who were diagnosed with and treated for HD at Pediatric Clinic in Sarajevo over the last 10 years (1st of January 1997 - 31st of December 2006). Until 2000 we used combination of chemotherapy and radiotherapy according to UKCCSG HD 9201 treatment protocol, and after the year 2000 protocol UKCCSG HD 2000 (ChlVPP / ABVD) was applied. The total number of the treated children 33. There were 17 boys (51,51 %) and 16 girls (48,49 %). In 10 patients (30,3 %) we found II A stage of HD, in 4 (12,1 %) II B stage of HD, in 6 children (18,8 %) stage III A, in 4 children (12,1 %) stage III B, in 4 children (12,1 %) stage IV A and in 5 (15,1 %) stage IV B. In 7 patients (21,2 %) relapse occurred, which demanded more aggressive chemotherapeutic treatment and radiotherapy too; while for 4 patients (12,1 %) in combination with bone marrow transplantation. Three patients (9,0 %) died. There are 30 children (91,0 %) who are alive and in either 1st or 2nd remission phase of HD. Secondary malignancies did not occur in any of the patients. Although many patients (58,1%) were diagnosed in an advanced stage of illness (III and IV) the results of HD therapy at Pediatric Clinic in Sarajevo are comparable to those in other European centers.
Highlights
Hodgkin’s disease (Hodgkin’s lymphoma) is the most frequent malignant lymphoma
Nodular sclerosing and mixed cellularity are found in children in almost equal ratio
In this paper we analyzed treatment success in children diagnosed with HB at Paediatric Clinic over ten years period
Summary
Hodgkin’s disease (Hodgkin’s lymphoma) is the most frequent malignant lymphoma. It is characterized by areas of lymphoid tissue hyperplasia where Reed-Sternberg (RS) cells are located. It begins as painless lymph node enlargement, most frequently on the neck, and disease expands to other lymph nodes and extra-lymphatic organs and infiltration of tissues may occur. In almost of cases of Hodgkin’s disease in childhood it is possible to prove the involvement of Epstein-Barr virus. Four types of Hodgkin’s lymphoma can be distinguished based on patho-histological analysis: lymphocyte predomination, nodular sclerosing, mixed cellularity and lymphocyte depletion. Most frequently used treatment protocols for the treatment of HD in children are: ABVD (Adriamycin, Bleomycin, Vincristine, DTIC), ChlVPP (Chlorambucil, Vinblastine, Procarbasine, Prednisone), COPP (Cyclophosphamide, Oncovin, Procarbazine, Prednisone) ( , )
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