THE RESULTS OF A SPECIFIC CBT INTERVENTION IN YOUNG HELP-SEEKING PATIENTS WITH SOCIAL DECLINE AND AN ULTRA-HIGH RISK FOR DEVELOPING A FIRST EPISODE OF PSYCHOSIS

Abstract

s of the 3rd Biennial Schizophrenia International Research Conference / Schizophrenia Research 136, Supplement 1 (2012) S1–S375 S17 the most recent update on randomised controlled intervention trials in this population and thereby contribute substantially to the discussion. Morrison and colleagues report on a large scale 5-site UK-based trial (n=288) comparing cognitive therapy (CT) with monitoring in community settings. In contrast to earlier pilot findings CT was not superior to monitoring in preventing transitions to psychosis. Van der Gaag and colleagues report on another large scale trial (n=201), which was performed at 4 sites in NL in which CT was applied to an enriched clinical sample which was treated in secondary care for an axis I disorder. CT was able to significantly reduce the number of transitions during an 18-month period. McGorry and co-workers report on an australian 12-month trial of risperidone (0.5-2 mg/day), cognitive therapy, or supportive therapy in 115 people at-risk of psychosis. Although the specific treatment conditions reduced transitions to psychosis from 20% in the control condition to 10%, this was a non-significant finding. Bechdolf et al. present the rationale and intermediate findings of a three arm trial in 10 centres throughout Germany (n=300) evaluating CT, aripiprazole and clinical management (CM) as well as placebo and CM for the prevention of psychosis. After having shown that the neuroprotective agent omega-3 PUFAs can reduce the risk of progression to psychotic disorder in a pilot study conducted in Austria (n=80) Amminger et al. present on baseline erythrocyte membrane fatty acids that predicted transition to psychotic disorder in this trial. C. Correll (USA) will discuss the results as regards their implications for the concept of the at-risk mental state, the risk-benefit ratio of interventions in this population and further research questions. EARLY DETECTION AND INTERVENTION EVALUATION FOR PEOPLE AT-RISK OF PSYCHOSIS Anthony P. Morrison, Paul French, Suzanne L.K. Stewart, Max Birchwood, David Fowler, Andrew I. Gumley, Peter B. Jones, Richard P. Bentall, Shon W. Lewis, Graham K. Murray, Paul Patterson, Kat Brunet, Jennie Conroy, Sophie Parker, Tony Reilly, Rory Byrne, Linda M. Davies, Graham Dunn School of Psychological Sciences, University of Manchester, Manchester, United