Abstract
The effect of extracts of corpora cardiaca on the rate of fluid secretion by the Malpighian tubules was tested. Saline extracts of storage lobes were found to be unstable at room temperatures and more than 75% of the activity was lost within 3 hr. The diuretic activity was stable in methanol extracts. Locust tubules were stimulated by diuretic hormones from Rhodnius, Glossina, and Periplaneta. Several compounds were found to mimic the action of the diuretic hormone: cyclic-AMP, dibutyryl cyclic-AMP, adrenalin, histamine, ecdysterone, cholesterol, and aldosterone produced marked increases in urine secretion. No effect was obtained with 5-hydroxytryptamine. Phentolamine inhibited the effects of adrenalin, but failed to inhibit the action of either locust diuretic hormone or cyclic-AMP.
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