Abstract
The effect of extracts of corpora cardiaca on the rate of fluid secretion by the Malpighian tubules was tested. Saline extracts of storage lobes were found to be unstable at room temperatures and more than 75% of the activity was lost within 3 hr. The diuretic activity was stable in methanol extracts. Locust tubules were stimulated by diuretic hormones from Rhodnius, Glossina, and Periplaneta. Several compounds were found to mimic the action of the diuretic hormone: cyclic-AMP, dibutyryl cyclic-AMP, adrenalin, histamine, ecdysterone, cholesterol, and aldosterone produced marked increases in urine secretion. No effect was obtained with 5-hydroxytryptamine. Phentolamine inhibited the effects of adrenalin, but failed to inhibit the action of either locust diuretic hormone or cyclic-AMP.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.