Abstract
Vitamin D exists in a variety of forms (vitamers). Vitamin D2 (ergocalciferol) and vitamin D3 are the two most common forms (calcitriol). VDRs (nutritional D receptors) are found in almost every tissue and cell. Gastrointestinal receptors are of therapeutic importance for the treatment of motility disorders. The present study was designed to demonstrate the modulatory effects of Vit.D on intestinal motility in adult male albino rats. Vitamin D was tested on intestinal strips with different intestinal receptor blockers (atropine sulfate, propranolol, verapamil, prazosin), followed by the addition of Vit.D on isolated intestinal strips. The obtained data demonstrated the optimal stimulatory effect of Ach on the isolated intestinal muscles for intestinal muscle contraction. Furthermore, the inhibitory effects of high-dose nicotine had no effect on the excitatory response. Therefore, it can be concluded that Vit.D has an effective stimulatory response on the isolated rat intestinal muscle.
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