Abstract
The feet of mice were irradiated with single doses or with 4, 8, 16 or 32 fractions of X rays, all in the same overall time of 43 days. Skin reactions and late deformities were scored and the results are discussed in terms of cell survival curve models. It is concluded that at low doses per fraction there is a significant component of irreparable damage, but it is not clear whether this is due to a high LET component of the radiation or to a variable sensitivity of the cells of the skin. The applicability of the Ellis formula is discussed and is found to be a reasonable approximation over a limited range of dose per fraction.
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