Abstract
Background: Both first and second phase insulin secretion (FPIS, SPIS, respectively) are important underlying factors for glucose metabolism. However, their responses to the treatment of diabetes have not been studied. This randomized, prospective study evaluated the change of FPIS and SPIS in newly diagnosed type 2 diabetes (T2DM).
Highlights
Insulin resistance and beta cell dysfunctions are two most important underlying defects of type 2 diabetes (T2DM) [1]
The Body mass index (BMI), hip circumference, diastolic blood pressure were higher while fasting plasma glucose (FPG) and A1C were lower after treatment
Several interesting points concerning insulin sensitivity and secretion were noted in this study
Summary
Insulin resistance and beta cell dysfunctions are two most important underlying defects of type 2 diabetes (T2DM) [1]. They start to deteriorate long before the clinically significant T2DM could be noted [2]. The responses or recovery of these two phases of insulin secretion after treatment have never been well studied Both first and second phase insulin secretion (FPIS, SPIS, respectively) are important underlying factors for glucose metabolism. Their responses to the treatment of diabetes have not been studied. Conclusion: In drug naive type 2 diabetes, SPIS could be better improved in subjects with younger age, lower baseline SPIS and higher triglycerides
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