Abstract
Abstract Gastroscopy and gastric biopsy have been carried out in human subjects before and after a course of conservative treatment for gastric ulceration or postgastrectomy dyspepsia due to gastritis. In the healing gastric ulcer the surrounding mucosa returns to histological normality, but in the postgastrectomy patient there is a persistent chronic gastritis around the stoma. In the gastric ulcer patient the cause of the gastritis may be the action of acid-pepsin on mucosa sensitized by bile reflux. In the postgastrectomy cases persistent gastritis may be due to the refluxing fluid itself causing the irritation, or to the absence of a protective effect exerted by the pyloric gland area.
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