The response-locked P3 component as indicator of pathophysiology in parkinson's disease

Abstract

Event Abstract Back to Event The response-locked P3 component as indicator of pathophysiology in parkinson's disease Rolf Verleger1* 1 University of Lübeck, Germany For long, the P3b component of the event-related EEG potential has been considered an indicator of response-independent processes. Correspondingly, studies on the P3 component in Parkinson's disease have looked at stimulus-locked averages only. Differences between patients and healthy persons remained diffuse. However, P3b actually forms a bridge between stimulus and response in healthy persons (Gerson et al., 2005; Verleger et al., 2005) with latencies and amplitudes of P3 peaks varying across trials in such a way that P3 waves are equally large in stimulus-locked and response-locked averages. Research on basal ganglia has suggested that making stimulus-response sequences precede automatically is a most relevant function of these structures. Therefore, when studying disorders of basal ganglia, as Parkinson's disease, it might make sense to focus on P3's function as a bridge between stimuli and responses. Thus, we compared stimulus- and response-locked P3b between patients with Parkinson's disease and healthy control groups in a choice-response task. In patients, P3 was distinctly smaller in response-locked than in stimulus-locked averages whereas, again, both amplitudes were equal in healthy participants. The difference in patients was due to a fronto-central negative shift, overlapping P3 during the final 100 ms before the response. Presumably, in order to compensate for the deficient automatic process, patients have to use additional activation of their supplementary motor areas. This difference is diluted when averaging is stimulus-locked. The specific reduction of response-locked P3 might qualify as a marker of basal-ganglia dysfunction. Keywords: Attention, Parkinson Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Poster Sessions: Neurophysiology of Cognition and Attention Citation: Verleger R (2011). The response-locked P3 component as indicator of pathophysiology in parkinson's disease. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00321 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 22 Nov 2011; Published Online: 28 Nov 2011. * Correspondence: Dr. Rolf Verleger, University of Lübeck, Lübeck, Germany, 665948@frontiersin.org Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Rolf Verleger Google Rolf Verleger Google Scholar Rolf Verleger PubMed Rolf Verleger Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.