Abstract
BackgroundPrevious studies demonstrated that the diversity and composition of respiratory microbiota in TB patients were different from healthy individuals. Therefore, the aim of the present analysis was to estimate the relative proportion of respiratory microbiota at phylum and genus levels among TB cases and healthy controls.MethodsThe PubMed and Google Scholar online databases were searched to retrieve relevant studies for the analysis. The statistical analysis was done using STATA version 11, pooled estimates are presented using graphs. The summary of findings in included studies is also presented in Table 1.ResultsThe phylum level analysis shows that the pooled proportions of Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, and Crenarchaeota were determined among tuberculosis patients and healthy controls. In brief, Firmicutes, and Proteobacteria were the most abundant bacterial phyla in both TB cases and healthy controls, composing 39.9 and 22.7% in TB cases and 39.4 and 19.5% in healthy controls, respectively. The genus level analysis noted that Streptococcus (35.01%), Neisseria (27.1%), Prevotella (9.02%) and Veillonella (7.8%) were abundant in TB patients. The Prevotella (36.9%), Gammaproteobacteria (22%), Streptococcus (19.2%) and Haemophilus (15.4%) were largely seen in healthy controls. Interestingly, Veillonella, Rothia, Leuconostoc were unique to TB cases, whereas Lactobacillus, and Gammaproteobacteria, Haemophilus, and Actinobacillus were identified only in healthy controls.ConclusionThe composition of the respiratory microbiota in TB patients and healthy controls were quite different. More deep sequencing studies are needed to explore the microbial variation in the respiratory system in connection with TB.
Highlights
Previous studies demonstrated that the diversity and composition of respiratory microbiota in TB patients were different from healthy individuals
A microbiota is a group of microbial communities, namely bacteria, archaea, protists, fungi, and viruses, which have been described in various parts of human body
It was generally assumed that the lower respiratory system was free of microbial agents, but recent advancement demonstrated that these airways contain a complex
Summary
Previous studies demonstrated that the diversity and composition of respiratory microbiota in TB patients were different from healthy individuals. A microbiota is a group of microbial communities, namely bacteria, archaea, protists, fungi, and viruses, which have been described in various parts of human body. The term microbiome is used to describe bacteria only, whereas the term mycobiome and virome are mostly used to describe fungal and viral populations, respectively. It was generally assumed that the lower respiratory system was free of microbial agents, but recent advancement demonstrated that these airways contain a complex. Studies revealed several microbial agents in the lung of diseased and healthy controls. The pulmonary microbiota studies in human beings showed that type and diversity of microbes are affected by disease conditions, antibiotic therapy, environmental factors, and socio-demographic factors.
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