Abstract
1. After due correction for complicating reactions, the rate of total gas uptake of normal diapausing pupae of the Cecropia silkworm in a carbon monoxide-oxygen mixture of 5 to 1 is found to be stimulated approximately 2-fold over the rate in air. 2. Ninety per cent of this extra gas uptake is due to a stimulation of the true respiration of the pupa. 3. The remaining ten per cent is due to the combustion of carbon monoxide to carbon dioxide. 4. The combustion of carbon monoxide is increased slightly when the metabolism of the pupa is enhanced following integumentary injury. 5. There is a slight fixation of carbon-14 in pupae under aerobic conditions presumably as a result of fixation of C14O2 manufactured from C14O by the pupa. 6. There is no detectable fixation of C14O in pupae exposed to this gas under anaerobic conditions. 7. After correction for carbon monoxide-combustion, it is clear that the enhanced oxygen uptake following integumentary injury of diapausing pupae is inhibited by carbon monoxide. 8. This carbon monoxide-inhibition is directly proportional to the enhancement of oxygen uptake following injury.
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