Abstract
Chronic chlorpromazine administration to rats (25 mg/Kg/day) for 30 days followed by a washout period of 10 days resulted in an increase in both measured maximum number of binding sites, B max, and the apparent dissociation constant, K d, for the binding of 3H-spiroperidol to neural membranes of the brain. When membrane suspensions were progressively diluted before the binding assay, it was found that the apparent B max did not change with dilution, remaining higher in membranes of chlorpromazine-treated rats than in controls. The apparent increase in K d, on the other hand, was found to be an artifact of the assay. Thus extrapolation of the measured or apparent K d value to infinite dilution resulted in identical value for K d regardless of the treatment.
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