The research status of immune dose of the parasite vaccine

Abstract

So far parasitic disease is still the one of the most important public health problems world-wide,especially in the developing countries.With the development of immunology and molecular biology technology,the parasite vaccine has become one of the important means of controlling parasitic diseases.Immune dose of the parasitic vaccine is one of the important factors for the immune effects.If the dose of vaccine is too low,the body can't be stimulated to produce enough immune response; if the dose of vaccine is too high,it may cause immune tolerance or toxic reactions.Therefore,to determine the appropriate immunization dose is the key of vaccine research.This article reviewed the research status of immune dose of several parasite vaccines,such as Schistosoma,Toxoplasma gondi and Trichinella spiralis. Key words: Parasite ; Vaccine; Immune dose