The research progress of the function and the change of dendritic cells in sepsis

Abstract

Background sepsis,induced by pathogenes which were brought through infection or trauma,lead to systemic inflammatory response syndrome and cause secondary injuries of bodies.It is one of the leading reasons of death in Intensive Care Unit.Objective To elaborate the changes of dendritic cells (DCs) and eventually manifest the critical role of DCs in sepsis.Contents Dysfunction of DCs is one of main reason in sepsis which induces immunosuppression.The number of DCs,especially immature DCs,decreased significantly,leading to the weakening of its antigen devouring ability.Much of dendritic cells,which were from the spleen of septic mice,stayed as mature phenotype,with the imbalance between the secretion of cytokines (IL-lO,and IL-12).Compared with normal mice,the dendritic cells isolated from septic mice,could not stimulate T cells proliferation efficiently.The characteristic mentioned above caused the body to have no responses to foreign pathogen,as a result leading the body to immunosuppressive states.Trend Increase the counts of dendritic cells and improve the ability of antigens presentation and cytokines production may become one of the potential targets for the treatment of sepsis. Key words: Sepsis ; Dendritic cells ; Immunosuppression ; Apoptosis ;