Abstract
SEPT9 is one of the 13 Septin homologous gene families involved in regulating numerous processes, including cell division, cell polarization, cell migration and mitochondrial division. Studies have shown that in many tumors, SEPT9 plays a role, especially in the field of colorectal cancer research, peripheral blood SEPT9 gene methylation detection is the research hotspot, the detection sensitivity and speciality rate relative to other glycoprotein tumor markers, fecal occult blood test and a fecal immunochemical test has more advantages, relative to colorectal colonoscopy invasive procedures it was more cost savings, at the same time with better compliance. This paper reviews the function of SEPT9, the relationship between SEPT9 and colorectal cancer, as well as the screening and diagnostic value of colorectal cancer. Key words: Colorectal neoplasms; SEPT9; Colorectal cancer screening; DNA methylation
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