The research progress of miRNA/lncRNA associated with spinal cord injury

Abstract

In recent years, with the rapid development of economy, the convenient transportation makes people travel more easily. However, the emergence of skyscrapers and various construction projects make high falling injury and traffic accident injury occur frequently, which are the most common types of spinal cord injury. Degeneration of nerve axons after spinal cord injury leads to paralysis of the distal limbs and death. So far, there have been no effective clinical therapy for the recovery of spinal cord function, but animal experiments have made encouraging progress. Recovery process of spinal cord injury involves axonal regeneration and the neural molecular genetic changes in the surrounding environment. Adult animals after spinal cord injury have different degrees of functional recovery in an appropriate growth environment with the benefit of some damaged neurons in the central nervous system. In this paper, we have discussed the changes of miRNA/LncRNA in the progress of regeneration and repair after spinal cord injury.