The research progress of complement in alcoholic liver disease

Abstract

Alcoholic liver disease (ALD) is one of the most important causes of chronic liver disease worldwide. With the increasing in the incidence of alcohol-induced liver disease, it has become increasingly hazardous to human health and has been affected globally. The pathogenesis of ALD is very complex and its exact pathogenesis still remains elusive. Studies have been confirming that activated complement components participate in the pathogenesis of ALD, indicating a new strategy for improving ALD through complement intervention. This article reviews the role and mechanism of complement involvement in alcoholic liver disease. Key words: Alcoholic liver disease; Complement