Abstract
ABSTRACTObjectives: Circular RNA (circRNA), a covalently closed loop structure lacking poly-adenylated tails, has attracted attention with the rapid development of its detection techniques such as bioinformatics and RNA sequencing. CircRNA plays important roles in several cell signaling pathways that are associated with cancer biogenesis, including acting as miRNA sponges, transcriptional regulators, protein adaptors and protein translators. The role of circRNA in hematological malignancy has been revealed recently. The purpose of this study was to explore the role of circRNA in hematological malignancy.Methods: A comprehensive literature review was conducted through Pubmed to summarize the published evidence on the circRNAs in hematological malignancies. English literature sources since 1976 were searched, using the terms circRNA, hematological malignancy.Results: CircRNAs can regulate the gene expression of hematological malignancies mainly through adsorbing several miRNAs. Some circRNAs are potential biomarkers and therapeutic targets in hematological malignancies, such as acute myloid leukemia (AML), chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL).Conclusion: CircRNAs play an important biological function and have great diagnostic and prognostic value in hematological malignancies.
Highlights
Circular RNA, as a closed circular non-coding RNA without a 5′-cap and a 3′-poly A tail, was first identified in viruses in 1970s [1]
It was generally believed that circRNA was the products of abnormal RNA splicing with no biological function
This review focused on the potential function of circRNA as diagnostic and prognostic markers and therapeutic targets for hematological malignancies
Summary
Circular RNA (circRNA), as a closed circular non-coding RNA without a 5′-cap and a 3′-poly A tail, was first identified in viruses in 1970s [1]. It was generally believed that circRNA was the products of abnormal RNA splicing with no biological function. With the rapid development of RNA sequencing and bioinformatics technology, the biological characteristics of circRNA have been gradually revealed. CircRNA was confirmed to be differentially expressed in cancer tissues and involved in the pathogenesis of various tumors including hematological malignancies [4]. CircRNA could enhance or inhibit the functions of target genes mainly by adsorbing microRNAs (miRNAs) which regulate gene expression, cell differentiation, apoptosis and metabolism [5,6]. Evidences have revealed that circRNA was closely related to the development of some hematologic malignancies (Table 1). This review focused on the potential function of circRNA as diagnostic and prognostic markers and therapeutic targets for hematological malignancies
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