Abstract
As disease genes of cerebral cavernous malformations, mutated CCM genes were initially considered only relating to the occurrence of cerebral cavernous malformations. further research of the genes and its encoding products confirm that CCM genes can participate in a variety of biological processes, including the Occurrence and the development of tumor. This article discusses recent understandings of the underlying mechanisms of CCM genes in different types of cancer based on a reciew of their structures, functions and interactions of CCM genes, and likely provide new prespectives and clues for further study of mechanism uderlying tumorigenesis. Key words: CCM1; CCM2; CCM3; Cancer; Cerebral Cavernous Malformations
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