Abstract
Objective In this study,we establishment the mouse cardiac ischemia repeffusion model,given two superoxide dismutase (SOD) analogues,in order to observe cardiac functions of myocardial ischemia reperfusion and ischemia reperfusion.Methods Establishment of mouse cardiac ischemia reperfusion model.Mice were given SOD analogues and phosphate buffer (PBS) in 5 min respectively before perfusion.By Evans blue and TTC staining determination of myocardial infarct area,laser Dopplermeasurement and changes of myocardial blood flow perfusion and heart function of myocardial ischemia,ischemia repeffusion injury of heart were observed changes.Results Mouse heart left anterior descending coronary artery ligation in mice with myocardial ischemia repeffusion injury model was constructed successfully,the success rate of the model 96％.Using SOD analogs to intervene before ischemia-reperfusion can obviously reduce the mouse cardiac reperfusioninjury center function,the area of myocardial infarction decreased from 65％ to 37％,the average change in mean arterial blood pressure (MABP) rate reduced from 33.3％ to 18.9％,the differences were statistically significant (P ＜ 0.05).Conclusion Oxygen free radicals is the key molecule of myocardial ischemia and reperfusion injury,SOD mimic can play a protective effect on myocardial ischemia repeffusion injury by scavenging oxygen free radicals. Key words: Myocardial ischemia; Reperfusion injury; Superoxide dismutase; Free radical
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