The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto&amp;apos;s Thyroiditis

Rongqin Dai,Yuzhi Liu,Jinbiao Zhang

doi:10.11648/j.ajls.20200802.11

Abstract

Objective: To assess the correlation of thyroid function and serum immunological indexes in patients with Hashimoto's thyroiditis. Method: To select 172 patients who have been clinically confirmed with HT. And they were divided into Hashimoto hyperthyroidism group within 39 cases, Hashimoto hypothyroidism group within 92 cases and normal Hashimoto's thyroid function group within 41 cases on the basis of Thyroid function. Besides, 50 healthy controls were control group. ECLIA was adopted to test the Thyroid function and antibody indicators of every group, and ELISA was employed to detect Th1 type cytokines (IL-2, IFN-γ) and Th2 type cytokines (IL-6, IL-10). Result: Every group with Hashimoto's thyroiditis was evidently higher than the normal one as well as the Hashimoto hypothyroidism group was higher than the Hashimoto hyperthyroidism group and the normal one in TPOAb and TGAb levels, in which the difference has statistical significance (P 0.05); Moreover, the IL-2, IFN-γ levels of the Hashimoto hyperthyroidism group and the normal Hashimoto's thyroid function group were distinctly higher than that of the Hashimoto hypothyroidism group; And the IL-6 and IL-10 levels were obviously higher than the Hashimoto hyperthyroidism group as well as the normal Hashimoto's thyroid function group (P<0.05). Besides, the TSH was positively correlated with the TPOAb and the IL-10. And FT4 was negatively correlated with the TPOAb, TGAb, IL-6. Not only the FT3 and TGAb but also the TT4 and IL-6 were in negative correlation. But the other indexes have no correlation. Conclusion: The patients with Hashimoto's thyroiditis have high TPOAb and TGAb levels. In addition, the TPOAb, TGAb and cytokines levels in the serum of HT patients with different thyroid function have evidently discrepancy, which may be closely related to the occurrence and development of the disease.

Highlights

The Hashimoto's thyroiditis (HT) is a typical thyroid disease about witch organ-specific and autoimmunity are mediated by T cells
They were divided into Hashimoto hyperthyroidism group within 39 cases, Hashimoto hypothyroidism group within 92 cases and normal Hashimoto's thyroid function group within 41 cases on the basis of Thyroid function
The HT diagnosis refers to the diagnostic criteria [6] in the 8th version of Internal Medicine published by the People's medical publishing house eighth printing Medicine, including: (1) the one with typical clinical features, such as diffusing goiter, tough texture, especially with thickening of isthmus and pyramidal lobe, etc., or thyroid peroxidase antibodies (TPOAb) or thyroid globulin antibodies (TGAb) positive, can be diagnosed; (2) the one without goiter, but with distinct TPOAb or TGAb increase as well as hypothyroidism can be diagnosed

Summary

Introduction

The Hashimoto's thyroiditis (HT) is a typical thyroid disease about witch organ-specific and autoimmunity are mediated by T cells. In the early stages of the disease, the patients’ thyroid function is normal or they will emerge transient hyperfunction. The causes of the HT are closely related to the body’s disorder cellular immune and humoral immune function of the thyroid epithelial cells [3]. There are rare researches on the indexes expression of serum antibodies and cytokines or others of patients with different thyroid function. By analyzing the changes in serum immune indexes of the HT patients with different thyroid function, this article is aimed at further discussing the HT pathogenesis as well as providing theory bases for the HT diagnoses and treatment

Methods

Results

Conclusion