Abstract
PurposeThe Oral Fat Tolerance Test (OFTT) is regarded as a repeatable measure used to assess postprandial triglyceride (TAG) levels, with higher levels observed in cardio-metabolic disorders. Acute aerobic exercise intervention before OFTT reduces the TAG response, but the repeatability of this effect is unknown. The aim of this study was to determine the repeatability of the abbreviated 4-h OFTT with and without immediate prior aerobic exercise.MethodsOn four separate days, healthy adult male participants underwent two 4-h OFTT (n = 10) and another two 4-h OFTT with 1-h of standardised moderate intensity aerobic exercise performed immediately before meal ingestion (n = 11). The OFTT meal composition included 75.4 g total fat, 21.7 g carbohydrate and 13.7 g protein. Venous blood was sampled at baseline and hourly up to 4 h after the OFTT meal ingestion, and TAG area under the curve (AUC) was calculated.ResultsNonparametric Bland–Altman analysis of 4-h TAG AUC revealed that 9 of 10 repeat measurements fell within ±15 % of the median TAG AUC for the OFTT. By contrast, two of 11 repeat measurements fell within ±15 % of the median TAG AUC for the OFTT undertaken with 1-h prior aerobic exercise.ConclusionsThe 4-h OFTT is a repeatable test of postprandial TAG responses in healthy men. However, aerobic exercise performed immediately before OFTT considerably increases the variability of TAG AUC. These findings have implications for interpretation of research studies investigating exercise intervention performed immediately before OFTT. Future studies should also investigate the repeatability of exercise performed 8–24 h before OFTT.
Highlights
The Oral Fat Tolerance Test (OFTT) is used to assess the capacity to adapt postprandial metabolic processes after a predefined oral fat load and evaluate cardio-metabolic health [1,2,3,4,5]
The 4-h OFTT is a repeatable test of postprandial TAG responses in healthy men
Aerobic exercise performed immediately before OFTT considerably increases the variability of TAG area under the curve (AUC)
Summary
The Oral Fat Tolerance Test (OFTT) is used to assess the capacity to adapt postprandial metabolic processes after a predefined oral fat load and evaluate cardio-metabolic health [1,2,3,4,5]. After oral fat consumption (>15 g), triglyceride (TAG) levels rise in the blood, typically peaking at 3–4 h and returning to baseline 6–8 h later [6]. The OFTT is not widely used in a clinical setting to assess cardio-metabolic function One reason for this could be the time demands of OFTT [10] which typically require postprandial measurements to be taken every 1 or 2 h for 5–8 h [11,12,13,14,15,16]. Recently an abbreviated OFTT (lasting 4-h) has been developed and validated [3, 10] This test would reduce the time constraints, improve the practicality of OFTT [10] and has been recommended by an expert consensus as clinically relevant
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