Abstract
1. 1. Toads have in their kidneys a renin-like enzyme and in their plasma an angiotensinogen-like substance. The incubation of toad plasma with kidney extracts gives rise to a pressor substance having properties similar to angiotensin. 2. 2. The renin content of the toad kidney expressed/g of kidney is higher in smaller animals. 3. 3. Male toads have almost twice the amount of renin found in the kidney of female toads of a similar weight. 4. 4. No seasonal variation in kidney renin was observed in male toads of the same weight studied through the year. 5. 5. Toad angiotensinogen releases angiotensin with fish renin, but not with mammalian renin. Toad renin releases angiotensin with chicken plasma but not with mammalian plasma.
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