The renal effect of prophylactic aminophylline therapy after cardiac surgery in infants

Abstract

The renal effect of prophylactic aminophylline therapy after cardiac surgery in infants Hwa jin Cho, In seok Jeong Chonnam National University Hospital, Republic of Korea Background/Purpose: Acute kidney injury (AKI) after pediatric cardiac surgery remains an important complication. Aminophylline, well-established bronchodilator, is also considered to be an effective diuretic and anti-inflammatory agent. We evaluated the effect of prophylactic aminophylline treatment after cardiac surgery in infants. Methods: From January 2011 to December 2014, 58 infants younger than 3 months who underwent operation for isolated ventricular septal defect were included and were classified to the prophylactic aminophylline therapy group (AMP group, n = 35) and the control group (n = 23). This is a retrospective analysis of urine output, fluid overload, and duration of oliguria/anuria between 2 groups in the postoperative period. Results: There was no statistical difference of age, body weight, and height between the groups. During 96-hour study period, increase of daily urine cumulative was higher in the AMP group after surgery than the control group. The serum creatinine level in AMP group was also significantly decreased at all times after surgery compared to the preoperative period (P b .001). There were no complications related to aminophylline administration. Conclusions: We suggest that administration of aminophylline could promote to increase urine output in the immediate postoperative period. The prospective studies are necessary to confirm the safety and effectiveness of prophylactic application.