Abstract
BackgroundPediatric rectal prolapse is a common issue in clinical practice. Among various managements, sclerotherapy is an important method to successfully treat pediatric rectal prolapse, especially for the first injection. The knowledge of the first injection of sclerotherapy can be revealed by a systemic review and meta-analysis of randomized clinical trials.MethodsWe performed a systematic search and a meta-analysis for the retrospective clinical studies of sclerotherapy in pediatric rectal prolapse. The comparison between remission and recurrence after the first injection of sclerotherapy was performed to find if the first injection of sclerotherapy can treat rectal prolapse completely. After a restricted selection, 17 studies involving 1,091 pediatric rectal prolapse subjects with sclerotherapy were enrolled in a variety of classifications of injection agents. The focused outcome was to check whether the first injection of sclerotherapy can achieve a remission status. The meta-analysis was performed by Review Manager 5.4.ResultsAmong the subjects receiving sclerotherapy, the meta-analysis favors the remission status after receiving the first injection of sclerotherapy. The meta-analysis results showed significant remission tests for the overall effect and significant heterogeneities in odds ratio and the fixed-effects model. The significant therapeutic effects remained, however, even after testing in the relative risk and the random-effects model.ConclusionsDespite significant heterogeneity and relatively low quality of evidence, the first injection of sclerotherapy may conceivably demonstrate therapeutic effects to help the patients of pediatric rectal prolapse achieve a remission status.
Highlights
Pediatric rectal prolapse is a significant issue in clinical practice
The exclusion criteria were the following: [1] Some parts of detailed data were unavailable in the content of the articles; [2] The authors did not respond or could not have access to the dataset, in which case the articles would be excluded as the category without detailed data; [3] The studies that do not belong to patients with rectal prolapse or sclerotherapy; and [4] Review articles
In the current meta-analysis, the results showed that the first injection of sclerotherapy might have a higher odds ratio (OR) to help the pediatric patients with rectal prolapse achieve a remission status
Summary
Pediatric rectal prolapse is a significant issue in clinical practice. Spontaneous resolution would be around 60–90% in pediatric rectal prolapse. Despite the high rate of spontaneous resolution, pediatric patients with rectal prolapse will suffer much if the condition will not spontaneously resolve. We planned to enroll the related articles of sclerotherapy in pediatric rectal prolapse. We wanted to confirm the remission effects of the first injection of sclerotherapy in pediatric rectal prolapse in the study design of systematic review and meta-analysis. Pediatric rectal prolapse is a common issue in clinical practice. Sclerotherapy is an important method to successfully treat pediatric rectal prolapse, especially for the first injection. The knowledge of the first injection of sclerotherapy can be revealed by a systemic review and meta-analysis of randomized clinical trials
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