Abstract
The action of three crude venom preparations ( V. ammodytes, A. piscivorus, Bombina variegata) and of purified venom fractions (melittin from bee venom, direct lytic factor and phospholipase A from cobra venom) upon the lysosomal membrane was investigated by measuring the release of acid hydrolases. All crude venom preparations used release acid hydrolases from lysosomes. Pure fractions from cobra venom ( Naja naja L.) exert a relatively weak but significant liberation of acid phosphatase and β-glucuronidase but not of cathepsin. Mixtures of phospholipase A and direct lytic factor are capable of solubilizing cathepsin, β-glucuronidase and acid phosphatase from lysosomes. The possible mechanism of this synergistic action is discussed.
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