Abstract
Background: Development and maintenance of penile erection requires the relaxation of corpus cavernosum smooth muscle (CCSM) cells and it is essentially mediated by nitric oxide (NO). Pausinystalia yohimbe bark is traditionally used for the treatment of erectile dysfunction (ED). Objectives and Methods: This study aimed to evaluate the effects of the methanolic extract of P. yohimbe bark (10 mg/ml) on isolated rabbit corpus cavernosum smooth muscle (CCSM). Results: Methanolic extract of P. yohimbe bark blocked contractions in CCSM induced by adrenergic agonists, through facilitating NO release from the endothelial cells. Conclusion: The obtained results revealed that, methanolic extract of P. yohimbe bark caused relaxation of CCSM that validates its traditional aphrodisiac property, thus it could be used to initiate and maintain erection in cases of erectile dysfunction.
Highlights
Disorders of sexual function are common among men of all ages, ethnicities and cultural backgrounds [1]
This study aimed to evaluate the effects of the methanolic extract of Pausinystalia yohimbe bark on isolated rabbit corpus cavernosum smooth muscles
Methanolic extract of P. yohimbe bark may cause relaxation of the precontracted corporal cavernosal tissue through inhibition of the phosphodiesterase type 5 (PDE-5), an enzyme which is predominantly expressed in the smooth muscle of the BL Adr 1 mg/ml
Summary
Disorders of sexual function are common among men of all ages, ethnicities and cultural backgrounds [1]. Some patients with psychogenic causes, stress disorders and depression, have an overactivity of alpha-agonists in their corpus cavernosum smooth muscle tissue, so a chemical imbalance may be to blame [4]. Development and maintenance of penile erection requires the relaxation of corpus cavernosum smooth muscle (CCSM) cells and it is essentially mediated by nitric oxide (NO). Objectives and Methods: This study aimed to evaluate the effects of the methanolic extract of P. yohimbe bark (10 mg/ml) on isolated rabbit corpus cavernosum smooth muscle (CCSM). Results: Methanolic extract of P. yohimbe bark blocked contractions in CCSM induced by adrenergic agonists, through facilitating NO release from the endothelial cells. Conclusion: The obtained results revealed that, methanolic extract of P. yohimbe bark caused relaxation of CCSM that validates its traditional aphrodisiac property, it could be used to initiate and maintain erection in cases of erectile dysfunction
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