The Relative Efficacy of Intracameral Moxifloxacin Injection Methods.

Abstract

To determine the amount of moxifloxacin remaining in the anterior chamber, immediately after its injection using three current injection methods, assuming mixing and fluid exchange with the anterior chamber contents during injection of the drug, and to determine the most desirable injection method. The University of Toronto Department of Ophthalmology and Vision Sciences and Institute of Biomedical Engineering. Mathematical modelling using first order mixing methods to assess mixing. The Kaiser method of injecting 0.5 mL x 100µg/0.1 mL does not achieve the desired 500μg level of moxifloxacin in the anterior chamber. The "straight from the bottle" method of injecting 0.1 mL x 500µg/0.1 mL is fraught with potential error, yielding a relatively unreliable final amount in the anterior chamber. Injecting 0.5 - 0.6 mL x 150µg/0.1 mL yields a result closest to the desired goal. Based on our calculation, the most accurate of current methods to deliver 500 µg moxifloxacin intracamerally is the method of 150µg/0.1 mL x 0.5 - 0.6 mL.