Abstract
SummaryRelative densities of sympathetic nerve terminals in 20 consecutive sections of both normally innervated (n = 10) and chronically denervated (n = 8) dog right atria were determined by comparative uptakes of [3H]norepinephrine. Results of analysis of neurally intact atria display a consistent gradient of [3H]norepinephrine with the highest concentration (130,000 dpm/g) in the tip of the atrial appendage and the lowest (30,000 dpm/g) in the - trial septum. The region containing the SA node was not distinguished by significantly high uptake. Atria of chronically dener-vated hearts had a markedly diminished [3H]norepinephrine uptake (average of 28,000 dpm/g). No gradient of radioactivity between sections was present in the dener-vated atria. These results indicate that (1) the canine right atrium has marked concentrations of sympathetic terminals in the appendage, (2) the technique of [3H]-norepinephrine uptake gives a quantitative evaluation of sympathetic nerve terminal density, and (3) the technique...
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More From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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