Abstract
In the pulmonary and mesenteric circulation, NO is known to be an important vasodilator during the period of postnatal transitional circulation. Little is known about the contribution of endothelium-derived hyperpolarizing factor(EDHF). We previously demonstrated that the NOS-inhibitor L-NMMA had little effect on ACh-mediated relaxation in femoral artery rings from newborn piglets, whereas it significantly inhibited relaxation in rings from 2 week old piglets. We therefore hypothesized that EDHF is more important than NO in mediating ACh-induced relaxation in newborn arteries, and that the relative importance of NO increases with age.
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