The relationships between the serum levels of resistin and pregnancy outcomes in gestational diabetes mellitus pregnant women with well-controlled glucose

Abstract

Objective To investigate the relationships among the serum levels of resistin,insulin resistance and pregnancy outcomes in gestational diabetes mellitus (GDM) pregnant women with well-controlled glucose.Methods A total of 98 GDM pregnant women of 24-28 weeks were recruited.Seventy-two cases of GDM with well-controlled glucose were defined as glycemic satisfied group,26 cases with unsatisfied glucose were defined as glycemic unsatisfied group.Ninety-five healthy pregnant women of 24-28 weeks at the same period were defined as healthy control group.Serum resistin,fasting plasma glucose (FPG),fasting insulin (FINS) of all pregnant women were measured at 24-28 weeks and 37-40weeks.The Home model insulin resistance index(HOMA-IR) was calculated.The pregnancy outcomes of the three groups were recorded and observed.Results Glycemic satisfied group had less incidence of premature birth,hypertension disorders complicating pregnancy,polyhydramnios,fetal macrosomia,meonatal asphyxia,meonatal hypoglycemia,cesarean section compared to glycemic unsatisfied group,and the differences were statistically significant (P＜ 0.05).When compared to healthy control group,no significant differences were found in incidence of premature birth,polyhydramnios,meonatal asphyxia,meonatal hypoglycemia,cesarean section in glycemic satisfied group(P ＞ 0.05),but there were significant differences in incidence of hypertension disorders complicating pregnancy and fetal macrosomia in glycemic satisfied group (P ＜0.05).At 24-28 weeks,resistin,FINS,FPG,HOMA-IR in glycemic satisfied group were significantly lower than those in glycemic unsatisfied group (P ＜ 0.05),but which were higher than those in healthy control group (P ＜ 0.05).At 37-40 weeks,FINS,HOMA-IR in glycemic satisfied group were significantly lower than those in glycemic unsatisfied group (P ＜ 0.05),but there were no significant differences in resistin,FPG among three groups (P ＞ 0.05).Conclusions The serum levels of resistin of GDM pregnant women decrease when blood glucose is well controlled,but high insulin resistance still exists.Well-controlled glucose can not completely improve pregnancy outcomes of GDM pregnant women. Key words: Resistin ; Diabetes,gestational; Insulin resistance; Pregnancy outcomes