Abstract
The relationship between serum dehydroepiandrosterone sulphate (DHEA-S) and anti-Mullerian hormone (AMH) levels has not been fully established. Therefore, we performed a large-scale cross-sectional study to investigate the association between serum DHEA-S and AMH levels. The study included a total of 2155 infertile women aged 20 to 46 years who were divided into four quartile groups (Q1 to Q4) based on serum DHEA-S levels. We found that there was a weak positive association between serum DHEA-S and AMH levels in infertile women (r = 0.190, p < 0.001). After adjusting for potential confounders, serum DHEA-S levels positively correlated with serum AMH levels in infertile women (β = 0.103, p < 0.001). Infertile women in the highest DHEA-S quartile category (Q4) showed significantly higher serum AMH levels (p < 0.001) compared with women in the lowest DHEA-S quartile category (Q1). The serum AMH levels significantly increased across increasing DHEA-S quartile categories in infertile women (p = 0.014) using generalized linear models after adjustment for potential confounders. Our data show that serum DHEA-S levels are positively associated with serum AMH levels.
Highlights
Anti-Mullerian hormone (AMH), a member of the transforming growth factor beta family, is secreted by granulosa cells of small growing follicles [1]
To the best of our knowledge, the current study is the largest cross-sectional study to examine the relationship between serum dehydroepiandrosterone sulphate (DHEA-S) and AMH levels in infertile women
This study demonstrated that higher serum DHEA-S levels correlated with higher serum AMH
Summary
Anti-Mullerian hormone (AMH), a member of the transforming growth factor beta family, is secreted by granulosa cells of small growing follicles [1]. Follicles release increased amounts of AMH until the follicles grow to 8 mm, and dominant follicle selection is initiated by follicle-stimulating hormone (FSH). When follicles grow to over 8 mm during the FSH-dependent stage, AMH expression rapidly declines until it is absent [2]. Serum AMH levels are strongly and positively associated with the number of growing follicles and can serve as a serum marker for functional ovarian reserve [3]. Serum AMH levels negatively correlate with age in adult women. After 25 years of age, serum AMH levels begin to drop steadily to undetectable levels at menopause [4,5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
