Abstract
Methods The adults with body mass index (BMI) more than 27 kg/m2 were enrolled in the study. General personal information, physical condition, TCMBC, biochemical, and SNPs were collected for eligible subjects. The body constitution questionnaire (BCQ) was used to evaluate the relationships between TCMBC tendency, biochemical values, and obesity-related SNPs. Results Obesity patients tended to have a yin deficiency constitution (YinDC) (n = 33, 66.0%); however, TCMBC in combination is not uncommon (30 subjects with more than two TCMBC in combination). For biochemical profiles, leptin was higher among patients with yang deficiency constitution (YangDC) (YangDC versus non-YangDC: 29.7 ± 24.8 versus 15.9 ± 9.9, P=0.020) and YinDC (YinDC versus non-YinDC: 28.8 ± 23.5 versus 14.4 ± 9.6, P=0.020). The leptin level was highest among YangDC subjects. Higher leptin was found among subjects with three-combined TCMBC than balanced TCMBC subjects who were not inclined to any of three TCMBC. For obesity-related SNPs, the adrenergic receptor beta-3 (ADRB3) gene tended to be high expression among YangDC (YangDC versus non-YangDC: 89.7% versus 71.4%, P=0.091) and uncoupling protein 1 (UCP1) tended to be high expression among phlegm-stasis constitution (PSC) (PSC versus non-PSC: 37.9% versus 9.5%, P=0.052). Conclusions The relationships between TCMBC, leptin, and SNPs present alternative viewpoints about TCMBC and could be used as a guide to treat obese patients.
Highlights
Obesity is a complex, chronic medical condition with a significant negative impact on human health [1]
Our study found that leptin was related to yang deficiency constitution (YangDC) and yin deficiency constitution (YinDC), and there was a trend between adrenergic receptor beta-3 (ADRB3)
We found that the leptin level was higher among YangDC and YinDC when compared to nonYangDC and non-YinDC subjects, respectively. e overall values of age, body mass index (BMI), and high leptin were similar to other studies about the obesity population, and these facts proved the need for other classification systems
Summary
Chronic medical condition with a significant negative impact on human health [1]. E associated UCP1 polymorphisms in the moderate obese group may regulate the impaired energy metabolism, which plays a significant role in the initial stages of obesity [12]. E constitution is broadly defined as the fundamental components that constitute a human being and includes the total expression of physiological, psychological, and pathological traits that characterize a person’s health [16]. It is a relatively stable characteristic of an organism and is affected by both nature and nurture. Traditional Chinese medicine body constitution (TCMBC) studies the overall physical condition affected by genetic and acquired factors. Our results could help to identify abnormal constitutions with a high risk for obesity and help clinicians focus on preventive strategies more effectively on these patients
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