Abstract
Purpose: To analyze the relationships between homocysteine, folate, MTH FR and TSER polymor- phism for postmenopausal women with osteoporotic compression fractures. Materials and Methods: Forty-three postmenopausal compression fracture patients and as many normal controls were included. The plasma homocysteine and folate levels were measured using a FPIA (fluorescent polarizing immunoassay) kit. The MTHFR and TSER genotypes were amplified by PCR (polymerase chain reaction) and separated by RFLP (restriction fragment length polymor- phism) in a 3.5% agarose gel. Results: The plasma folate level was significantly lower in the postmenopausal women with osteoporotic compression fractures, particularly in the MTHFR 677CT and TSER 2R (�� ) genotypes. However, the plasma homocysteine level and MTHFR C677T polymorphism were similar to the control group. Conclusion: A low folate level and the TSER 2R (�� ) genotype can be associated with osteoporotic compression fractures in postmenopausal women.
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