Abstract
Imbalance between the production and removal of reactive oxygen species (ROS) has been used for characterizing Oxidative stress. Extra amount of ROS are hazardous and can lead damages to the cells resulting in harsh diseases. For cancer, diabetes, psychological disorders and age-related disorders, latent of ROS in induction of alteration and DNA harm is a critical factor. Regarding these finding, the current research was planned to test the relationship between cognitive neuropsychological state and oxidative markers and genotoxicity in radiology staff. Total Number of 47 radiology staff, working in the radiology center of a referral University Hospital in Shiraz, were invited in the study. The participants were occupationally exposed to low-dose ionizing radiation (x-ray) for more than 2 years. Psychological disorder was analyzed by SCL-90-R. In the plasma, lipid peroxidation, DNA harm, catalase, superoxide dismutase, myeloperoxidase, and glutathione peroxidase activity were calculated. Associations between parameters were measured by using Pearson correlation coefficient and multivariate linear regression analyses. As a result, there was a positive considerable connection between catalase and paranoid ideation, Obsessive-Compulsive, Anxiety and total. Furthermore, the correlation between psychoticism, Interpersonal Sensitivity, Paranoid Ideation and DNA damage was positive. There were positive relationships between superoxide dismutase and psychomotor speed, initiative/energy, selective attention and verbal memory. So, there were significant relationships among interpersonal sensitivity, somatization, depression and gender. But, there were no major relationships among psychological distress, history workers and oxidative stress. In so many words, Oxidative stress and genotoxicity result in psychological disorders in radiology staff. So, radiology staff should have more attention, as they suffered from some psychological disorders.
Highlights
It would be mentioned that when there is no balance between the production of free radicals and reactive oxygen species (ROS), oxidative stress is created and antioxidant defense system is consisted of antioxidant enzymes like superoxide dismutase of copper, zinc and, manganese, and small molecule antioxidants such as glutathione, vitamin E and vitamin C
Materials and Methods The materials which were applied in this research are as follow: Tris base, tetraethoxy propane (MDA), 2-thiobarbituric acid (TBA), trichloroacetic acid (TCA), n-butanol, dithiobis-2-nitrobenzoic acid (DTNB), 2,4,6tripyridyl-striazine (TPTZ) from Sigma-Aldrich Chemie (Gmbh Munich, Germany), HNO3, H2SO4, HCL, NaCl, PdCl2 from Merck Chemical Co. (Darmstadt, Germany), and ELISA kits for oxidative stress biomarkers and DNA damage from Cayman Chemical Co. (Michigan, USA)
There is positive correlationship between oxidative stress and cognitive neuropsychological disorders. These results are related to the conclusion of other researches done on the psychological disorders due to oxidative stress, for example, [6]-[19] [22] [28]
Summary
It would be mentioned that when there is no balance between the production of free radicals and reactive oxygen species (ROS), oxidative stress is created and antioxidant defense system is consisted of antioxidant enzymes like superoxide dismutase of copper, zinc and, manganese, and small molecule antioxidants such as glutathione, vitamin E and vitamin C. Some free radicals such as nitrogen reactive species (RNS) and reactive oxygen species (ROS) lead oxidative damage to RNA DNA lipids and proteins [1]. As a matter of fact, utilizing oxygen in people at risk raised to 1.5 times and approximately 2% of the oxygen is changed tore active oxygen species (ROS), this oxygen is used by cells in the procedure of oxidative phosphorylation [5]
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