Abstract
Under standard conditions sixteen local anesthetics and closely related compounds were evaluated for intravenous mouse toxicity, threshold irritant concentration, intracutaneous local anesthetic activity, and toxicity to mouse liver epithelial and mouse connective tissue cell cultures. Highly significant correlations of the logarithms between the threshold irritant concentration and the toxicity to the cell cultures were found, and also between the intravenous mouse toxicity and the local anesthetic potency. The results using the two cell cultures were in good agreement. A smaller but significant correlation was found between the intracutaneous local anesthetic potency and the threshold irritating concentrations. Possible interrelationships between irritancy, local anesthetic potency, systemic toxicity, and cell toxicity were discussed.
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