Abstract
BackgroundThe fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship of serum fatty acid profile and ECHDC3 expression with the extent of coronary lesion.MethodsFifty-nine individuals aged 30 to 74 years and undergoing elective cinecoronariography for the first time were enrolled in the present study. The extent of coronary lesion was assessed by the Friesinger index and patients were classified as without lesion (n = 18), low lesion (n = 17), intermediate lesion (n = 17) and major lesion (n = 7). Serum biochemistry, fatty acid concentration, and ECHDC3 mRNA expression in blood were evaluated.ResultsElevated serum levels of oleic acid and total monounsaturated fatty acids were observed in patients with low and intermediate lesion, when compared to patients without lesion (p < 0.05). ECHDC3 mRNA expression was 1.2 fold higher in patients with low lesion than in patients without lesion (p = 0.020), and 1.8 fold lower in patients with major lesion patients than in patients with low lesion (p = 0.023).ConclusionIncreased levels of monounsaturated fatty acids, especially oleic acid, and ECHDC3 upregulation in patients with coronary artery lesion suggests that these are independent factors associated with the initial progression of cardiovascular disease.
Highlights
The fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression
Since there is no study evaluating the relationship between fatty acid (FA) levels and genes related to Cardiovascular disease (CVD) development and progression yet, we aimed to evaluate the serum FA profile and ECHDC3 expression in patients with varying extent of coronary lesion
According to the Friesinger index, the patients were classified into four groups: without lesion (n = 18), low lesion (n = 17), intermediate lesion (n = 17), and major lesion (n = 7)
Summary
The fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We assessed the relationship of serum fatty acid profile and ECHDC3 expression with the extent of coronary lesion. The early diagnosis of CVD along with proper assessment of cardiovascular risk is crucial for further reduction of health care costs and mortality rates. Duarte et al Lipids in Health and Disease (2016) 15:144 within 2 h after an acute coronary syndrome, suggesting this gene could be a potential novel biomarker for the early stage of an acute episode [3]. The function of ECHDC3 or its involvement with cardiovascular diseases is scarcely explored in the literature, which might be due to its recent identification. ECHDC3 is presumed to be involved in β-oxidation, the most important and wellknown pathway for fatty acid (FA) oxidation [5,6,7]
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