THE RELATIONSHIP OF THE BLOOD PRESSURE VARIABILITY AND HEART RATE VARIABILITY: A CANONICAL CORRELATION STUDY

Abstract

Objective: To determine the association of the blood pressure variability (BPV) and heart rate variability (HRV) derived from ambulatory blood pressure monitoring (ABPM). Design and method: 2886 patients who perfected the 24 hours ABPM from September 2018 to January 2020 were enrolled and we performed Pearson correlation analysis and Canonical correlation analysis (CCA) to identify the relationship of the dynamic blood pressure (BP) and heart rate (HR) in singer variable aspect and whole set of variate respect, respectively. Results: Pearson correlation analysis described the strong connection between the mean value of the systolic and diastolic BP and average value of HR during nighttime and morning surge(r = 0.438,0.475,0.504,0.547,P-value less than 0.01).Results of CCA showed a canonical correlation of 0.934 in the first canonical pair (P-value less than 0.01). Moreover, standard canonical coefficient marked the mean value of BP and HR with the largest efficiency compared to maximum, minimum and standard deviation. The value of BP and HR during nighttime and morning surge with loading approaching 0.5 are key factor of their own variable set. The nighttime average systolic BP attached importance to HRV set and nighttime HR mean value to BPV set(crossing loading:0.533,0.504).Redundancy analysis represent the total interpretative quantity of 12 valued correlation of BPV and HRV set are 58.3% and 90.4%.Whereas,14.6% and 18.8% are the total redundancy accounted by the opposite variable set. In addition, the association more than the reference substance comprising of age and gender. Conclusions: With regard to the result of 24 hours ABPM, we cannot neglect the circadian rhythms and tight relationships of BPV and HRV. To better manage the BP and autonomic nervous function, respectively, mitigating the mean value of the BP and HR during nighttime and morning surge should be put on the agenda.