The relationship of pulp polyp with the presence and concentration of immunoglobulin E, histamine, interleukin‐4 and interleukin‐12

Abstract

The aim of this study was to evaluate the relationship between pulp polyp formation and immunoglobulin E (IgE), histamine and interleukin-4 (IL-4) as the most important mediators which are involved in allergy. Thirty-two samples including 16 pulp polyps and 16 normal pulps were gathered. After homogenising the pulpal tissue samples, enzyme-linked immunosorbent assay (ELISA) techniques were used to assess the concentration of IgE, histamine, IL-4 and IL-12. The two groups showed statistically significant differences in terms of both the concentration and presence of IgE, histamine and IL-4 (P < 0.001); both presence and concentration of IgE, histamine and IL-4 were higher in pulp polyps than in normal pulps. There is not any significant difference between case and control groups regarding IL-12. The results of this study give rise to the possibility of type I hypersensitivity reaction being involved in pulp polyp's pathogenesis.