The Relationship of MMP-3 Levels with the Degree of Helicobacter Pylori Gastritis

Abstract

Gastritis is an inflammation in the stomach tissue that can occur either acutely or gradually as a chronic condition. Incidence of gastritis in Indonesia is high, which is 274,396 cases out of 238,452,952 inhabitants. One of the most common causes of gastritis is Helicobacter pylori (H. pylori). Matrix metalloproteinase (MMP) is a dependent proteinase that is able to break down almost all extracellular matrix proteins. It is known from several studies that MMP is closely related to gastric ulcer disease and cancer. At present, in vivo and in vitro studies have established the activation of several MMPs associated with H. Pylori infection. There were 80 samples obtained through consecutive sampling in March-June 2019. Gastritis was ensured by endoscopy (Olympus, Tokyo, Japan). H.pylori is established through a change in color from yellow to red, magenta, pink, or orange in the examination of Campylobacter Like Organism test (CLO). MMP-3 level examination using a serum MMP3 was measured using RayBio Human MMP-3 and MICA ELISA kits (Norcross, GA). Data were collected and analyzed using SPSS version 22. There was a significant relationship between MMP-3 levels and the severity of H. pylori gastritis, namely between the degree of neutrophil infiltration (p = 0.016), atrophy (p = 0.001), and intestinal metaplasia (p <0.001). Keywords: Gastritis, Helicobacter Pylori, MMP-3.