The Relationship of IL 17a, Vit-D Levels and some Biochemical Markers with Psoriasis and the Effect of Oral Vitamin D Supplementation on Clinical Amelioration of the Disease

Abstract

The aim of the study was to measure vitamin D levels before and after giving specific doses of it. Patients with psoriasis have an imbalance in vitamin D levels, as vitamin D levels have been correlated with the level of disease progression. Psoriasis incidence rates after administration of vitamin D at a dose of 1 month every day 2000 IU, then the second and third month every week 10,000 IU for period a 3-month indicate that the size of the affected area did not expand or stopped expanding. Also in our study, interleukin-17 levels and lipid profile showed some changes, indicating that high levels of vitamin D may reduce inflammation or inflammatory diseases by contributing to immune system activation. There were notable changes in average lipids and the effect was likely caused by changes in vitamin D levels, which play an important role in lipid metabolism. There was also a decrease in calcium levels.