Abstract
Many of earlier reports suggest a connection betwee n hepatitis C virus (HCV) infection and type2 diabe tes (T2D). However, the results are conflicting. The aim of ou r study was to investigate the seroprevalence of bo th HCV infections and hepatitis B virus (HBV) in type 2 di abetes mellitus (DM) patients in Yemen as well as t he risk of hepatitis for development diabetes mellitus.120 pat ients were enrolled for this study: 50 patients wit h T2D, 70 with chronic hepatitis(29 with HCV,36 with HBV and 5 were infections with HCV and HBV) along with 50 healthy control. Investigated hepatitis C and B patients fo r blood sugar, determined hepatitis B surface antig en (HBsAg) and anti-HCV in both groups, measured by chromatographic and enzyme-linked immunosorbent assay(ELSIA). We found that in T2D-patients 7 out of 50 (14%) detect ed with hepatitis, 5 (10 %) of 50 T2D-patients had evidence of HCV infection compared to 2 (4%) with HBV. The development diabetic mellitus among 70 hepatitis C and B patients 8 out of 70 (11.4%), 3 HBV 36 (8.3%), 4 HCV 29 (13.7%), 1 Co-infection HBV and HCV 5 (20%) compared to 1 (2%) without association in 50 contro l adults. The antibodies levels in T2D-patients wit h HCV viremia were significantly higher than those in HBV patients. HCV viremia, sex, age, family history of diabetes and tobacco use was found to be difference independent risk factors for diabetes.
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