The relationship of galanin immunoreactive nerve fibers to glandular cells in the anterior pituitary in the monkey

Abstract

The anterior pituitary is known to be regulated by hypothalamic hormones via the portal system. However, our recent studies have demonstrated the presence of a substantial amount of substance P (SP)-, calcitonin gene-related peptide (CGRP)- and galanin (GAL)- immunoreactive (ir) nerve fibers with numerous varicosities in the anterior pituitaries of the Macaca mulatta monkey. The present study investigated the relationship of the GAL-ir nerve fibers to the glandular cells. The M. mulatta monkeys were used and the sections of the anterior pituitary were double immunostained. GAL-ir nerve fibers and/or varicosities were found in proximity to contact directly with corticotropes, somatotropes, lactotropes, gonadotropes and thyrotropes without any exception. These findings indicate that a direct neural factor may be involved in the regulation of adenohypophyseal secretion.