Abstract
Aspects of sleep stage evaluation and analysis of alpha and delta EEG frequencies in sleep were shown to be related to musculoskeletal pain and mood disturbance in patients with ‘fibrositis syndrome’. Patients were treated at bedtime for 3 weeks with either chlorpromazine, 100 mg (8 patients), or l-tryptophan, 5 g (7 patienys). Chlorpromazine, but not l-tryptophan, was associated with increased slow wave sleep and amelioration of pain and mood symptoms. Mean percent time/min or mean percent power/min of alpha frequency during NREM and REM sleep correlated with overnight increase in pain measures, hostility, and decrease in energy. On the other hand, mean percent time/min of delta in NREM sleep was related to overnight decrease in pain and mean percent delta power/min was associated with decreased anxiety and hostility, and increased energy.
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