Abstract
BackgroundThe aim of the study was to explore the relationship between vitamin D status and islet function in patients with type 2 diabetes mellitus.MethodsThe participants were recruited from Hebei General Hospital. Basic characteristics and blood indicators were collected after fasting overnight. The data were analyzed statistically using SPSS 22.0. Analysis of variance, a nonparametric test, or a trend Chi-square test was used for the comparisons. The association between 25-hydroxy vitamin D and modified homeostasis model assessment-β was assessed using multivariate ordinal logistic regression.ResultsOne hundred seventy-four patients aged 26 to 79 years with type 2 diabetes mellitus were included in this study. Patients with vitamin D deficiency had a lower modified homeostasis model assessment-β level compared with those without vitamin D deficiency. There were differences in body mass index, diabetes course, glycosylated hemoglobin, fasting blood glucose, fasting blood C-peptide, triglyceride, and 25-hydroxy vitamin D among different modified homeostasis model assessment-β groups based upon the tertiles. 25-hydroxy vitamin D, as continuous or categorical variables, was positively related to modified homeostasis model assessment-β whether or not cofounding factors were adjusted.ConclusionThere is an association between increased 25-hydroxy vitamin D levels and improvement in modified homeostasis model assessment-β function in patients with type 2 diabetes mellitus.Trial registrationCross-sectional trails ChiCTR2000029391, Registration Date: 29/01/2020.
Highlights
The aim of the study was to explore the relationship between vitamin D status and islet function in patients with type 2 diabetes mellitus
A meta-analysis of randomized controlled trials (RCTs) showed that vitamin D supplementation decreased glycosylated hemoglobin (HbA1c) and fasting blood glucose (FBG) levels in type 2 diabetes mellitus (T2DM) patients with vitamin D deficiency or without obesity for patients with vitamin D insufficiency or sufficiency, vitamin D supplementation did not change the status of glycemic control [6]
Modified homeostasis model assessment (HOMA)-β levels based on vitamin D deficiency Vitamin D deficiency was defined as 25-hydroxyvitamin D (25OHD) < 20 ng/ mL
Summary
The aim of the study was to explore the relationship between vitamin D status and islet function in patients with type 2 diabetes mellitus. Vitamin D insufficiency or deficiency was strongly related with accelerated development of IR [5]. A low 25OHD level was related to an increased risk of T2DM and poor glucose control. A meta-analysis of randomized controlled trials (RCTs) showed that vitamin D supplementation decreased glycosylated hemoglobin (HbA1c) and FBG levels in T2DM patients with vitamin D deficiency or without obesity for patients with vitamin D insufficiency or sufficiency, vitamin D supplementation did not change the status of glycemic control [6]. Low 25OHD level increased the risk or the severity of complications, such as diabetic peripheral neuropathy [7] and diabetic retinopathy [8]
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